Telomere shortening in kidneys with age.

  title={Telomere shortening in kidneys with age.},
  author={Anette Melk and Vido Ramassar and Lisa M. H. Helms and Robert Clifton Moore and David Rayner and Kim Solez and Philip F. Halloran},
  journal={Journal of the American Society of Nephrology : JASN},
  volume={11 3},
The histology and function of the kidney deteriorates with age and age-related diseases, but the mechanisms involved in renal aging are not known. In vitro studies suggest that telomere shortening is important in replicative senescence, and is accelerated by stresses that increase replication. This study explored the relationship between age and telomere length in surgical samples from 24 human kidneys, which were either histologically normal (17) or displayed histologic abnormalities (7… CONTINUE READING


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