Telomere shortening in kidneys with age.

@article{Melk2000TelomereSI,
  title={Telomere shortening in kidneys with age.},
  author={Anette Melk and Vido Ramassar and Lisa M. H. Helms and Robert Clifton Moore and David Rayner and Kim Solez and Philip F. Halloran},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2000},
  volume={11 3},
  pages={444-53}
}
The histology and function of the kidney deteriorates with age and age-related diseases, but the mechanisms involved in renal aging are not known. In vitro studies suggest that telomere shortening is important in replicative senescence, and is accelerated by stresses that increase replication. This study explored the relationship between age and telomere length in surgical samples from 24 human kidneys, which were either histologically normal (17) or displayed histologic abnormalities (7… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 66 extracted citations

Telomere Length Assessment for Prediction of Organ Transplantation Outcome. Future or Failure: A Review of the Literature

Medical science monitor : international medical journal of experimental and clinical research • 2017
View 6 Excerpts
Highly Influenced

Accelerated senescence in the kidneys of patients with type 2 diabetic nephropathy.

American journal of physiology. Renal physiology • 2008
View 8 Excerpts
Highly Influenced

Molecular mechanisms of renal aging.

Kidney international • 2017
View 1 Excerpt

Renal Aging: Causes and Consequences.

Journal of the American Society of Nephrology : JASN • 2017

References

Publications referenced by this paper.
Showing 1-10 of 42 references

Telomere length predicts replicative capacity of human fibroblasts.

Proceedings of the National Academy of Sciences of the United States of America • 1992
View 3 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…