Telomere shortening in human coronary artery diseases.

  title={Telomere shortening in human coronary artery diseases.},
  author={Masayuki Ogami and Yoshihiro Ikura and Masahiko Ohsawa and Toshihiko Matsuo and Soichiro Kayo and N Yoshimi and Eishu Hai and Nobuyuki Shirai and Shoichi Ehara and Ryushi Komatsu and Takahiko Naruko and Makiko Ueda},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  volume={24 3},
BACKGROUND Increased cell turnover in response to injury is considered to be important in the development of atherosclerotic plaques. Telomere shortening has been shown to be associated with cell turnover. We assessed the telomere length of human coronary endothelial cells to clarify whether there is a relationship between telomere shortening and coronary artery disease (CAD). METHODS AND RESULTS Coronary endothelial cells were obtained from 11 patients with CAD who underwent autopsy and 22… CONTINUE READING
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