Telomere shortening in familial and sporadic pulmonary fibrosis.

Abstract

RATIONALE Heterozygous mutations in the coding regions of the telomerase genes, TERT and TERC, have been found in familial and sporadic cases of idiopathic interstitial pneumonia. All affected patients with mutations have short telomeres. OBJECTIVES To test whether telomere shortening is a frequent mechanism underlying pulmonary fibrosis, we have… (More)
DOI: 10.1164/rccm.200804-550OC

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