Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.

@article{Counter1992TelomereSA,
  title={Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.},
  author={Christopher M. Counter and Ariel A. Avilion and C Lefeuvre and Nick N. Stewart and Carol W Greider and Calvin B. Harley and Silvia Bacchetti},
  journal={The EMBO journal},
  year={1992},
  volume={11 5},
  pages={1921-9}
}
Loss of telomeric DNA during cell proliferation may play a role in ageing and cancer. Since telomeres permit complete replication of eukaryotic chromosomes and protect their ends from recombination, we have measured telomere length, telomerase activity and chromosome rearrangements in human cells before and after transformation with SV40 or Ad5. In all mortal populations, telomeres shortened by approximately 65 bp/generation during the lifespan of the cultures. When transformed cells reached… CONTINUE READING
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