Telomere shortening and DNA damage of embryonic stem cells induced by cigarette smoke.

@article{Huang2013TelomereSA,
  title={Telomere shortening and DNA damage of embryonic stem cells induced by cigarette smoke.},
  author={Junjiu Huang and Maja Okuka and Weisi Lu and John C M Tsibris and Mark P. McLean and David Lawrence Keefe and Lin Liu},
  journal={Reproductive toxicology},
  year={2013},
  volume={35},
  pages={89-95}
}
Embryonic stem cells (ESCs) provide a valuable in vitro model for testing toxicity of chemicals and environmental contaminants including cigarette smoke. Mouse ESCs were acutely or chronically exposed to smoke components, cigarette smoke condensate (CSC), or cadmium, an abundant component of CSC, and then evaluated for their self-renewal, apoptosis, DNA damage and telomere function. Acute exposure of ESCs to high dose of CSC or cadmium increased DNA damage and apoptosis. Yet, ESCs exhibited a… CONTINUE READING

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Prenatal Tobacco Exposure Shortens Telomere Length in Children.

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco • 2017

References

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Evidence for human lung stem cells.

The New England journal of medicine • 2011

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