Telomere sequence content can be used to determine ALT activity in tumours

  title={Telomere sequence content can be used to determine ALT activity in tumours},
  author={Michael Lee and Erdahl T. Teber and Oliver Wendall Holmes and Katia Nones and Ann-Marie Patch and Rebecca A. Dagg and Loretta M. S. Lau and Joyce Lee and Christine E Napier and Jonathan W. Arthur and Sean M. Grimmond and N. K. Hayward and Peter A Johansson and Graham J. Mann and Richard A Scolyer and James S Wilmott and Roger R Reddel and John V. Pearson and Nicola Waddell and Hilda A Pickett},
  booktitle={Nucleic acids research},
The replicative immortality of human cancer cells is achieved by activation of a telomere maintenance mechanism (TMM). To achieve this, cancer cells utilise either the enzyme telomerase, or the Alternative Lengthening of Telomeres (ALT) pathway. These distinct molecular pathways are incompletely understood with respect to activation and propagation, as well as their associations with clinical outcomes. We have identified significant differences in the telomere repeat composition of tumours that… CONTINUE READING
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