Telomere restoration and extension of proliferative lifespan in dyskeratosis congenita fibroblasts.

@article{Westin2007TelomereRA,
  title={Telomere restoration and extension of proliferative lifespan in dyskeratosis congenita fibroblasts.},
  author={Erik R. Westin and Elizabeth Chavez and Kimberly M. Lee and Françoise A. Gourronc and Soraya Riley and Peter M. Lansdorp and Frederick D. Goldman and Aloysius J. Klingelhutz},
  journal={Aging cell},
  year={2007},
  volume={6 3},
  pages={383-94}
}
Dyskeratosis congenita (DC), an inherited bone marrow failure syndrome, is caused by defects in telomerase. Somatic cells from DC patients have shortened telomeres and clinical symptoms are most pronounced in organs with a high cell turnover, including those involved in hematopoiesis and skin function. We previously identified an autosomal dominant (AD) form of DC that is caused by mutations in the telomerase RNA component (TER). In this study, we evaluated whether retroviral expression of TER… CONTINUE READING