Telomere resolution in the Lyme disease spirochete.

  title={Telomere resolution in the Lyme disease spirochete.},
  author={George Chaconas and Philip E Stewart and Kit Tilly and James L Bono and Patr{\'i}cia Viana da Rosa},
  journal={The EMBO journal},
  volume={20 12},
The genus Borrelia includes the causative agents of Lyme disease and relapsing fever. An unusual feature of these bacteria is a genome that includes linear DNA molecules with covalently closed hairpin ends referred to as telomeres. We have investigated the mechanism by which the hairpin telomeres are processed during replication. A synthetic 140 bp sequence having the predicted structure of a replicated telomere was shown to function as a viable substrate for telomere resolution in vivo, and… CONTINUE READING

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