Telomere length variations in 6 mucosal cell types of gastric tissue observed using a novel quantitative fluorescence in situ hybridization method.

@article{Aida2007TelomereLV,
  title={Telomere length variations in 6 mucosal cell types of gastric tissue observed using a novel quantitative fluorescence in situ hybridization method.},
  author={Junko Aida and Naotaka Izumiyama-Shimomura and Ken-ichi Nakamura and Akio Ishii and Naoshi Ishikawa and Naoko Honma and Rie Kurabayashi and Makoto Kammori and Steven S. Poon and Tomio Arai and K Takubo},
  journal={Human pathology},
  year={2007},
  volume={38 8},
  pages={1192-200}
}
We developed a novel method for evaluating telomere length in 6 cell types of noncancerous and cancerous mucosal tissues from 11 cases of gastric neoplasm using the quantitative fluorescence in situ hybridization method with telomere and centromere peptide nucleic acid probes. Our telomere length estimates were determined from the background-corrected telomere intensity divided by the background-corrected centromere intensity (telomere-to-centromere ratio). Our results indicated that telomere… CONTINUE READING