Telomere length variation in normal and malignant human tissues.

@article{Schmitt1994TelomereLV,
  title={Telomere length variation in normal and malignant human tissues.},
  author={Holger Schmitt and Nikolaus Blin and Heinrich Zankl and Harry Scherthan},
  journal={Genes, chromosomes & cancer},
  year={1994},
  volume={11 3},
  pages={
          171-7
        }
}
Tissue and tumor specific length variation of telomere (TTAGGG)n repeats was studied in DNAs from various normal and malignant tissues. DNA was isolated from bone marrow and blood cells, malignant tissues, and established tumor cell lines. Nonisotopic Southern hybridization revealed a reduction of telomere repeat arrays in 14 of the 35 tumors analyzed. However, other cases (60%) showed no reduction, or even an increase, in telomeric length. Our finding of elongated telomere stretches in several… CONTINUE READING

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