Telomere length is reset during early mammalian embryogenesis.

  title={Telomere length is reset during early mammalian embryogenesis.},
  author={S. Sch{\"a}tzlein and A. Lucas-Hahn and E. Lemme and W. Kues and M. Dorsch and M. Manns and H. Niemann and K. Rudolph},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={101 21},
  • S. Schätzlein, A. Lucas-Hahn, +5 authors K. Rudolph
  • Published 2004
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences of the United States of America
  • The enzyme telomerase is active in germ cells and early embryonic development and is crucial for the maintenance of telomere length. Whereas the different length of telomeres in germ cells and somatic cells is well documented, information on telomere length regulation during embryogenesis is lacking. In this study, we demonstrate a telomere elongation program at the transition from morula to blastocyst in mice and cattle that establishes a specific telomere length set point during embryogenesis… CONTINUE READING
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