Telomere length is a prognostic factor in neuroblastoma.

  title={Telomere length is a prognostic factor in neuroblastoma.},
  author={Anat Ohali and Smadar Avigad and Shifra Ash and Yacov Goshen and Drorit Luria and Meora Feinmesser and Rina Zaizov and Isaac Yaniv},
  volume={107 6},
BACKGROUND Maintenance of telomeres, in most instances by reactivation of telomerase, is obligatory for the indefinite proliferation of tumor cells. The objective of this study was to evaluate telomere length and telomerase activity (TA) as markers for progression and prognosis in neuroblastoma. METHODS Primary tumor samples from 51 patients were analyzed for telomere length and TA and were correlated with known prognostic parameters and outcome. RESULTS Telomere length had a highly… CONTINUE READING

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