Telomere length in the colon declines with age: a relation to colorectal cancer?

  title={Telomere length in the colon declines with age: a relation to colorectal cancer?},
  author={Jacintha O'sullivan and Rosa Ana Risques and Margaret T. Mandelson and Lu Chen and Teresa A. Brentnall and Mary P Bronner and Melissa P Macmillan and Ziding Feng and Joseph R. Siebert and John D. Potter and Peter S. Rabinovitch},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  volume={15 3},
Telomeres shorten with age, which may be linked to genomic instability and an increased risk of cancer. To explore this association, we analyzed telomere length in normal colorectal tissue of individuals at different ages using quantitative-fluorescence in situ hybridization (Q-FISH) and quantitative-PCR (Q-PCR). Using Q-FISH, we also examined the histologically normal epithelium adjacent to, or distant from, colon adenomas and cancers, in addition to the neoplasms. Q-FISH and Q-PCR showed that… CONTINUE READING

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