Telomere length in circulating serum DNA as a novel non-invasive biomarker for cirrhosis: a nested case-control analysis.

@article{Wan2012TelomereLI,
  title={Telomere length in circulating serum DNA as a novel non-invasive biomarker for cirrhosis: a nested case-control analysis.},
  author={Shaogui Wan and Faasld Hie-Won Hann and Ronald E. Myers and Xiaoying Fu and Richard S. Hann and Su Hee Kim and Heng Juan Tang and Jinliang Xing and Hushan Yang},
  journal={Liver international : official journal of the International Association for the Study of the Liver},
  year={2012},
  volume={32 8},
  pages={
          1233-41
        }
}
BACKGROUND & AIMS Previous studies have indicated that telomere length is associated with altered risk of various tumours including hepatitis B virus (HBV)-related hepatocellular carcinoma. However, the association between telomere length and the risk of cirrhosis has not been reported. METHODS In this nested case-control study, we used real-time quantitative PCR to determine the relative telomere length (RTL) in serum DNA samples from 100 HBV-related cirrhosis cases and 100 frequency-matched… CONTINUE READING
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