Telomere length in circulating leukocytes is associated with lung function and disease.

  title={Telomere length in circulating leukocytes is associated with lung function and disease.},
  author={Eva Albrecht and Elina Sillanp{\"a}{\"a} and S Karrasch and Alexessander da Silva Couto Alves and Veryan Codd and Iiris Hovatta and Jessica L. Buxton and Christopher P. Nelson and Linda Broer and Sara H{\"a}gg and Massimo Mangino and Gonneke A H M Willemsen and Ida Surakka and Manuel A. R. Ferreira and Najaf Amin and Ben A. Oostra and Heli M. B{\"a}ckmand and Markku Peltonen and Seppo S Sarna and Taina Rantanen and Sarianna Sipil{\"a} and Tellervo Korhonen and Pamela A. F. Madden and Christian Gieger and Rudolf A. J{\"o}rres and Joachim Heinrich and J{\"u}rgen Behr and Rudolf Maria Huber and Annette Peters and Konstantin Strauch and H Erich Wichmann and Melanie Waldenberger and Alexandra I. F. Blakemore and Eco J de Geus and Dale R. Nyholt and Anjali K. Henders and P{\"a}ivi Piiril{\"a} and Aila M. Rissanen and Patrik Karl Erik Magnusson and Ana Vi{\~n}uela and Kirsi Hannele Pietil{\"a}inen and Nicholas G. Martin and Nancy L Pedersen and Dorret I. Boomsma and Tim D. Spector and Cornelia M van Duijn and Jaakko Kaprio and Nilesh J. Samani and Marjo-Riitta Jarvelin and Holger Schulz},
  journal={The European respiratory journal},
  volume={43 4},
Several clinical studies suggest the involvement of premature ageing processes in chronic obstructive pulmonary disease (COPD). Using an epidemiological approach, we studied whether accelerated ageing indicated by telomere length, a marker of biological age, is associated with COPD and asthma, and whether intrinsic age-related processes contribute to the interindividual variability of lung function. Our meta-analysis of 14 studies included 934 COPD cases with 15 846 controls defined according… CONTINUE READING
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