Telomere length in breast cancer patients before and after chemotherapy with or without stem cell transplantation

@article{Schrder2001TelomereLI,
  title={Telomere length in breast cancer patients before and after chemotherapy with or without stem cell transplantation},
  author={Carolina P. Schr{\"o}der and G Bea A Wisman and Steven de Jong and Winette T. A. van der Graaf and Marcel H J Ruiters and Nanno H. Mulder and Lou H. M. F. de Leij and Ate G. J. van der Zee and E. G. E. de Vries},
  journal={British Journal of Cancer},
  year={2001},
  volume={84},
  pages={1348 - 1353}
}
High-dose chemotherapy and peripheral blood stem cell transplantation (PBSCT) may accelerate telomere length loss in haematopoietic stem cells. As data including pre-and post-treatment samples are lacking, we studied leukocyte telomere length and telomerase activity before and after treatment in breast cancer patients randomized to receive 5 adjuvant courses FEC (5-FU, epirubicin and cyclophosphamide) (n= 17), or 4 × FEC followed by high-dose cyclophosphamide, thiotepa, carboplatin and… CONTINUE READING
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