Telomere length in Hutchinson-Gilford progeria syndrome.

@article{Decker2009TelomereLI,
  title={Telomere length in Hutchinson-Gilford progeria syndrome.},
  author={Michelle L Decker and Elizabeth Chavez and Irma Vulto and Peter M. Lansdorp},
  journal={Mechanisms of ageing and development},
  year={2009},
  volume={130 6},
  pages={377-83}
}
Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare premature aging disorder caused by mutations in the gene LMNA, which encodes the nuclear matrix protein lamin A. Previous research has shown that the average telomere length in fibroblasts from HGPS patients is shorter than in age-matched controls. How mutations in lamin A lead to shortened telomere lengths is not known nor is the contribution of individual chromosome ends to the low average length understood. To measure the telomere length… CONTINUE READING
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