Telomere length homeostasis responds to changes in intracellular dNTP pools.

  title={Telomere length homeostasis responds to changes in intracellular dNTP pools.},
  author={Amitabha Gupta and Sushma Sharma and Patrick Reichenbach and Lisette Marjavaara and Anna Karin Nilsson and Joachim Lingner and Andrei Chabes and Rodney Rothstein and Michael Chang},
  volume={193 4},
Telomeres, the ends of linear eukaryotic chromosomes, shorten due to incomplete DNA replication and nucleolytic degradation. Cells counteract this shortening by employing a specialized reverse transcriptase called telomerase, which uses deoxyribonucleoside triphosphates (dNTPs) to extend telomeres. Intracellular dNTP levels are tightly regulated, and perturbation of these levels is known to affect DNA synthesis. We examined whether altering the levels of the dNTP pools or changing the relative… CONTINUE READING
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