Telomere length homeostasis and telomere position effect on a linear human artificial chromosome are dictated by the genetic background

@inproceedings{Weuts2012TelomereLH,
  title={Telomere length homeostasis and telomere position effect on a linear human artificial chromosome are dictated by the genetic background},
  author={An Weuts and Thierry Voet and Jelle Verbeeck and Nathalie Lambrechts and Evelyne Wirix and Luc Schoonjans and Sophie Danloy and Peter Marynen and Guy Froyen},
  booktitle={Nucleic acids research},
  year={2012}
}
Telomere position effect (TPE) is the influence of telomeres on subtelomeric epigenetic marks and gene expression. Previous studies suggested that TPE depends on genetic background. As these analyses were performed on different chromosomes, cell types and species, it remains unclear whether TPE represents a chromosome-rather than genetic background-specific regulation. We describe the development of a Linear Human Artificial Chromosome (L-HAC) as a new tool for telomere studies. The L-HAC was… CONTINUE READING