Telomere length and telomerase complex mutations in pediatric acute myeloid leukemia

@article{Aalbers2013TelomereLA,
  title={Telomere length and telomerase complex mutations in pediatric acute myeloid leukemia},
  author={Anna M Aalbers and Rodrigo T. Calado and Neal S. Young and Ch Michel Zwaan and C Wu and Sachiko Kajigaya and Eva A. Coenen and Andr{\'e} Baruchel and Karin P W Geleijns and Val{\'e}rie de Haas and Gertjan J L Kaspers and Taco Willem Kuijpers and Dirk Reinhardt and Jan Trka and Martin Zimmermann and Rob Pieters and V. H. J. van der Velden and M M van den Heuvel-Eibrink},
  journal={Leukemia},
  year={2013},
  volume={27},
  pages={1786-1789}
}
Pediatric acute myeloid leukemia (AML) is a heterogeneous malignant disease, characterized by abnormal proliferation and impaired differentiation of myeloid cells. Acquired cytogenetic aberrations such as t(8;21)(q22;q22)/AML-ETO, inv(16)(p13q22)/ CBFb-MYH11, t(15;17)(q22;q21)/PML-RARa, rearrangements involving MLL and molecular aberrations in genes such as FLT3, NPM1, CEBPA and WT1 are involved in AML pathogenesis and are prognostic factors for treatment outcome. Recently, constitutional loss… CONTINUE READING