Telomere length and replicative aging in human vascular tissues.

  title={Telomere length and replicative aging in human vascular tissues.},
  author={Eugene Chang and Calvin B. Harley},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={92 24},
Because repeated injury of the endothelium and subsequent turnover of intimal and medial cells have been implicated in atherosclerosis, we examined telomere length, a marker of somatic cell turnover, in cells from these tissues. Telomere lengths were assessed by Southern analysis of terminal restriction fragments (TRFs) generated by HinfI/Rsa I digestion of human genomic DNA. Mean TRF length decreased as a function of population doublings in human endothelial cell cultures from umbilical veins… CONTINUE READING


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