Telomere length and pancreatic cancer risk: breaking down the evidence.

  title={Telomere length and pancreatic cancer risk: breaking down the evidence.},
  author={Eric J Duell},
  volume={66 6},
Telomeres, located at the ends of chromosomes and composed of a protein complex and tandem repeats of TTAGGG nucleotides, function to protect chromosomes from end-to-end fusions, breakage and degradation in dividing cells. Due to the inherent nature of DNA replication (‘the end replication problem’) and oxidative stress—telomeres gradually shorten with age. This has been demonstrated cross-sectionally in most tissues examined including the pancreas, and especially in cells with extensive… CONTINUE READING
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