Telomere length abnormalities occur early in the initiation of epithelial carcinogenesis.

  title={Telomere length abnormalities occur early in the initiation of epithelial carcinogenesis.},
  author={Alan K Meeker and Jessica L. Hicks and Christine A Iacobuzio-Donahue and Elizabeth Anne Montgomery and William H Westra and Theresa Y Chan and Brigitte M. Ronnett and Angelo M De Marzo},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={10 10},
PURPOSE Telomeres help maintain chromosomal integrity. Dysfunctional telomeres can cause genetic instability in vitro and an increased cancer incidence in telomerase knock out mouse models. We recently reported that telomere shortening was a prevalent alteration in human prostate, pancreas, and breast cancer precursor lesions. In the present study, we address whether the previous findings are broadly applicable to human epithelial cancer precursors in general. EXPERIMENTAL DESIGN Surgical… CONTINUE READING


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