Telomere elongation by hnRNP A1 and a derivative that interacts with telomeric repeats and telomerase

@article{LaBranche1998TelomereEB,
  title={Telomere elongation by hnRNP A1 and a derivative that interacts with telomeric repeats and telomerase},
  author={H{\'e}l{\`e}ne LaBranche and Sophie Dupuis and Yaacov Ben-David and Maria-Rosa Bani and Raymund J Wellinger and Benoit Chabot},
  journal={Nature Genetics},
  year={1998},
  volume={19},
  pages={199-202}
}
Telomeric DNA of mammalian chromosomes consists of several kilobase-pairs of tandemly repeated sequences with a terminal 3´ overhang in single-stranded form. Maintaining the integrity of these repeats is essential for cell survival; telomere attrition is associated with chromosome instability and cell senescence, whereas stabilization of telomere length correlates with the immortalization of somatic cells. Telomere elongation is carried out by telomerase, an RNA-dependent DNA polymerase which… CONTINUE READING