Telomere dysfunction and genome instability.

@article{Fras2012TelomereDA,
  title={Telomere dysfunction and genome instability.},
  author={Cristina Fr{\'i}as and Judit Pampalona and Anna Genesc{\`a} and Laura Tusell},
  journal={Frontiers in bioscience},
  year={2012},
  volume={17},
  pages={2181-96}
}
The nucleoprotein complexes that cap the very ends of the eukaryotic chromosomes, named telomeres, are indispensable for cell viability. Telomeric DNA shortens in each cell division until it cannot exert end-protective functions in human somatic cells. Additionally, several proteins have been described to play a key role in telomere homeostasis preventing chromosome extremities to be recognized as double-stranded breaks (DSBs). When telomeres become dysfunctional, either through excessive… CONTINUE READING
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