Telomere dysfunction and evolution of intestinal carcinoma in mice and humans

@article{Rudolph2001TelomereDA,
  title={Telomere dysfunction and evolution of intestinal carcinoma in mice and humans},
  author={Karl Lenhard Rudolph and Melissa Millard and Marcus W. Bosenberg and Ronald A. Depinho},
  journal={Nature Genetics},
  year={2001},
  volume={28},
  pages={155-159}
}
Telomerase activation is a common feature of advanced human cancers and facilitates the malignant transformation of cultured human cells and in mice. These experimental observations are in accord with the presence of robust telomerase activity in more advanced stages of human colorectal carcinogenesis. However, the occurrence of colon carcinomas in telomerase RNA (Terc)-null, p53-mutant mice has revealed complex interactions between telomere dynamics, checkpoint responses and carcinogenesis. We… CONTINUE READING

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