Telomere dysfunction: a new player in radiation sensitivity.

  title={Telomere dysfunction: a new player in radiation sensitivity.},
  author={Anna Genesc{\`a} and Marta L{\'o}pez Mart{\'i}n and Laura Latre and David Ramos Soler and Judit Pampalona and Laura Tusell},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  volume={28 12},
Human individuals often exhibit important differences in their sensitivity to ionising radiation. Extensive literature links radiation sensitivity with impaired DNA repair which is due to a lack of correct functioning in many proteins involved in DNA-repair pathways and/or in DNA-damage checkpoint responses. Given that ionising radiation is an important and widespread diagnostic and therapeutic tool, it is important to investigate further those factors and mechanisms that underlie individual… CONTINUE READING