Telomere dynamics in cancer progression and prevention: fundamental differences in human and mouse telomere biology

@article{Wright2000TelomereDI,
  title={Telomere dynamics in cancer progression and prevention: fundamental differences in human and mouse telomere biology},
  author={Woodring E. Wright and Jerry W. Shay},
  journal={Nature Medicine},
  year={2000},
  volume={6},
  pages={849-851}
}
Cells from the telomerase knockout mouse immortalize with an approximately ten million-fold greater frequency than human cells. In this commentary, Wright and Shay discuss the implications of this difference between mice and men and its relationship to cancer. 
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