Telomere dynamics determine episodes of anticancer drug resistance in rat hepatoma cells.

@article{Deschatrette2004TelomereDD,
  title={Telomere dynamics determine episodes of anticancer drug resistance in rat hepatoma cells.},
  author={Jean Deschatrette and K. Heng Ng and Laurent Gouthi{\`e}re and Jo{\`e}lle Maign{\'e} and Samia Guerroui and Claire Wolfrom},
  journal={Anti-cancer drugs},
  year={2004},
  volume={15 7},
  pages={671-8}
}
Clinical and experimental observations indicate that resistance to anticancer drugs may be spontaneously reversible over time, but the mechanisms of this reversal are unknown. The resistance of cultured hepatoma cells to methotrexate (MTX) and cisplatin was followed for 9 months. Cells were exposed to three treatments: MTX 200 nM for 24 h or 15 nM continuously and cisplatin 50 microM for 2 h. We investigated the relation between the temporal pattern of cell resistance and the previously… CONTINUE READING