Telomere deregulations possess cytogenetic, phenotype, and prognostic specificities in acute leukemias.

@article{Capraro2011TelomereDP,
  title={Telomere deregulations possess cytogenetic, phenotype, and prognostic specificities in acute leukemias.},
  author={Val{\'e}rie Capraro and Linda Zane and Delphine Poncet and David P{\'e}rol and Perrine Galia and Claude Joseph Preudhomme and Nathalie Bonnefoy-B{\'e}rard and Eric Gilson and X. Thomas and Mohamed El-Hamri and Youcef Chelghoun and Mauricette Michallet and E Wattel and Franck Mortreux and David Sibon},
  journal={Experimental hematology},
  year={2011},
  volume={39 2},
  pages={195-202.e2}
}
OBJECTIVE Telomeres are protected by tightly regulated factors and elongated by telomerase. Short and/or deprotected chromosomes are recombinogenic and thereby cancer prone. MATERIALS AND METHODS Together with the quantification of telomerase activity (TA), measuring telomere length (TL) and expression of the genes that govern telomere protection and elongation are useful for assessing telomere homeostasis. RESULTS By these means we demonstrate that TL, hTERT, and TA are in the order acute… CONTINUE READING

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