Telomere attrition and accumulation of senescent cells in cultured human endothelial cells.

@article{Hastings2004TelomereAA,
  title={Telomere attrition and accumulation of senescent cells in cultured human endothelial cells.},
  author={Richard P Hastings and Madiha Qureshi and Rakesh Verma and Peter S Lacy and Bryan P Williams},
  journal={Cell proliferation},
  year={2004},
  volume={37 4},
  pages={317-24}
}
The human umbilical vein endothelial cell (HUVEC) is an important model of the human endothelium that is widely used in vascular research. HUVECs and the adult endothelium share many characteristics including progression into senescence as the cells age. Despite this, the shortening of telomeres and its relationship to the progression into senescence are poorly defined in HUVECs. In this study of several HUVEC lines we show notable consistency in their growth curves. There is a steady decline… CONTINUE READING