Telomere and Telomerase as Targets for Cancer Therapy

@article{Tian2010TelomereAT,
  title={Telomere and Telomerase as Targets for Cancer Therapy},
  author={Xiaoping Tian and B. Chen and Xiao-chuan Liu},
  journal={Applied Biochemistry and Biotechnology},
  year={2010},
  volume={160},
  pages={1460-1472}
}
  • Xiaoping Tian, B. Chen, Xiao-chuan Liu
  • Published 2010
  • Medicine, Chemistry
  • Applied Biochemistry and Biotechnology
  • Telomere maintenance and telomerase reactivation is essential for the transformation of most human cancer cells. Telomere shortening to the threshold length, mutations of the telomere-associated proteins, and/or telomerase RNA lead to telomeric dysfunction and therefore genomic instability. Telomerase up-regulation in 85% of human cancer cells has become a hallmark of cancers, hence a promising target for anticancer therapy. In this review, we discuss the mechanism of cancer due to telomere… CONTINUE READING

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    Novel anticancer therapeutics targeting telomerase.
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