Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA

@article{Blasco1997TelomereSA,
  title={Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA},
  author={M. Blasco and H. Lee and M. Hande and E. Samper and P. Lansdorp and R. DePinho and C. Greider},
  journal={Cell},
  year={1997},
  volume={91},
  pages={25-34}
}
To examine the role of telomerase in normal and neoplastic growth, the telomerase RNA component (mTR) was deleted from the mouse germline. mTR-/- mice lacked detectable telomerase activity yet were viable for the six generations analyzed. Telomerase-deficient cells could be immortalized in culture, transformed by viral oncogenes, and generated tumors in nude mice following transformation. Telomeres were shown to shorten at a rate of 4.8+/-2.4 kb per mTR-/- generation. Cells from the fourth mTR… Expand
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References

SHOWING 1-10 OF 83 REFERENCES
Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.
Differential regulation of telomerase activity and telomerase RNA during multi-stage tumorigenesis
Telomerase activity in normal and malignant murine tissues.
The RNA component of human telomerase
Developmental and tissue-specific regulation of mouse telomerase and telomere length.
  • K. Prowse, C. Greider
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1995
Telomere elongation in immortal human cells without detectable telomerase activity.
Functional characterization and developmental regulation of mouse telomerase RNA
Specific association of human telomerase activity with immortal cells and cancer.
Increased telomerase activity in mouse skin premalignant progression.
...
1
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3
4
5
...