Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA
@article{Blasco1997TelomereSA, title={Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA}, author={Mar{\'i}a A. Blasco and Han-Woong Lee and Manoor Prakash Hande and Enrique Samper and Peter M. Lansdorp and Ronald A. DePinho and Carol W. Greider}, journal={Cell}, year={1997}, volume={91}, pages={25-34} }
2,081 Citations
Severe growth defect in mouse cells lacking the telomerase RNA component
- BiologyNature Genetics
- 1998
Accompanying the continual telomere shortening, the growth rate of Terc-deficient ES cells was gradually reduced after more than 300 divisions, and then cell growth virtually stopped, showing that telomerase-dependent telomeres maintenance is critical for the growth of mammalian cells.
Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis
- Biology, MedicineNature Genetics
- 2000
It is shown that late-generation Terc−/− mice, which have short telomeres and are telomerase-deficient, are resistant to tumour development in multi-stage skin carcinogenesis, and predicted that an anti-telomerase–based tumour therapy may be effective in epithelial tumours.
Growth defects in mouse telomerase RNA-deficient cells expressing a template-mutated mouse telomerase RNA.
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- 2009
Telomere Maintenance in Telomerase-Deficient Mouse Embryonic Stem Cells: Characterization of an Amplified Telomeric DNA
- BiologyMolecular and Cellular Biology
- 2000
Characterization of the telomersic structures in one of the survivor mTER−/− cell lines showed amplification of the same tandem arrays of telomeric and nontelomeric sequences at most of the chromosome ends, which implicatescis/trans amplification as one mechanism for the telomerase-independent maintenance of telomeres in mammalian cells.
Telomerase inhibition in a mouse cell line with long telomeres leads to rapid telomerase reactivation.
- BiologyExperimental cell research
- 2008
Inhibition of telomerase limits the growth of human cancer cells
- BiologyNature Medicine
- 1999
It is shown here that expression of a mutant catalytic subunit of human telomerase results in complete inhibition of telomer enzyme activity, reduction in telomere length and death of tumor cells, validating human telomersase reverse transcriptase as an important target for the development of anti-neoplastic therapies.
Dysfunctional telomeres promote genomic instability and metastasis in the absence of telomerase activity in oncogene induced mammary cancer
- BiologyMolecular carcinogenesis
- 2013
It is concluded that short telomeres promote metastasis in the absence of telomerase activity in neu oncogene driven mammary tumors.
Telomere shortening and apoptosis in telomerase-inhibited human tumor cells.
- Biology, MedicineGenes & development
- 1999
It appears that telomerase inhibition in cells with short telomeres lead to chromosomal damage, which in turn trigger apoptotic cell death, and this results provide the first direct evidence that telomersase is required for the maintenance of human tumor and immortal cell viability.
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