Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA

@article{Blasco1997TelomereSA,
  title={Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA},
  author={M. Blasco and H. Lee and M. Hande and E. Samper and P. Lansdorp and R. DePinho and C. Greider},
  journal={Cell},
  year={1997},
  volume={91},
  pages={25-34}
}
To examine the role of telomerase in normal and neoplastic growth, the telomerase RNA component (mTR) was deleted from the mouse germline. mTR-/- mice lacked detectable telomerase activity yet were viable for the six generations analyzed. Telomerase-deficient cells could be immortalized in culture, transformed by viral oncogenes, and generated tumors in nude mice following transformation. Telomeres were shown to shorten at a rate of 4.8+/-2.4 kb per mTR-/- generation. Cells from the fourth mTR… Expand
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