Telomere Length in the Newborn

  title={Telomere Length in the Newborn},
  author={Koji Okuda and Arlene D. Bardeguez and Jeffrey P. Gardner and Paulette Rodriguez and Vijaya L. Ganesh and Masayuki Kimura and Joan H. Skurnick and Girgis Awad and Abraham Aviv},
  journal={Pediatric Research},
Telomere length is similar in different organs of the human fetus but variable among fetuses. During extrauterine life telomere length is highly variable among individuals and longer in women than men. In the present work we addressed the following questions:1) Are there sex-related differences in telomere length at birth? 2) Is there synchrony (i.e. correlation in length) of telomeres in tissues within the newborn? 3) Is the variability in telomere length among newborns as large as that in… 

Figures and Tables from this paper

Racial differences in maternal and umbilical cord blood leukocyte telomere length and their correlations
Telomere length may differ by race at birth due to both inherited and racial differences in maternal factors, as determined by linear regression and maternal–cord blood Spearman correlations.
Telomere length comparison between oral cells and blood cells among neonates.
The cause of high telomere length variability in the oral source is not clear although the presence of leukocytes among cheek cells cannot be excluded, therefore, for telomeres length measurement purpose blood should be given preference over the Oral source.
Cord blood telomere shortening associates with increased gestational age and birth weight in preterm neonates.
It is suggested that telomere length may be a novel biomarker alone or in combination with traditional indicators for the prediction of weight development in preterm neonates.
The effect of intrauterine growth on leukocyte telomere length at birth
  • A. StefaA. Lamprokostopoulou E. Charmandari
  • Medicine
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
  • 2018
Intrauterine growth does not seem to affect leukocyte telomere length (LTL) at birth, and a larger sample size of IUGR, LGA, and AGA neonates are required to determine whether growth at birth influences LTL.
Maternal pre-pregnancy body mass index and newborn telomere length
Maternal pre-pregnancy BMI is associated with shorter newborn telomere lengths as reflected by cord blood and placental telomeres, and these findings support the benefits of a pre-Pregnancy healthy weight for promoting molecular longevity from early life onwards.
Telomere length in early childhood is associated with sex and ethnicity
The data suggest that telomere lengths are highly variable and variability between individuals arise from early age, influenced partly by sex and ethnicity, and may reflect the heritability of telomeres in genetically less complex populations.
Prenatal stress and newborn telomere length.
Sex difference in leukocyte telomere length is ablated in opposite-sex co-twins
It is suggested that the sex difference in LTL, seen in the general population, is largely determined in utero, perhaps by the intrauterine hormonal environment.


Telomeres in Neonates: New Insights in Fetal Hematopoiesis
Telomere length in the leukocyte fraction of umbilical cord blood samples from 15 preterm and 11 full-term neonates was measured using the telomere restriction fragment assay, consistent with the known almost maximal proliferation rate of hematopoietic progenitor cells before 32 weeks of gestation.
Synchrony in telomere length of the human fetus
It is concluded that synchrony in telomere length exists among tissues of the human fetus, and this synchrony is apparently lost during extrauterine life.
Shortened telomere length in white blood cells of patients with IDDM.
The shortened TRF length of WBCs of patients with IDDM likely reflects a marked reduction in the TRFlength of subsets of W BCs that play a role in the pathogenesis of IDDM.
Telomere length inversely correlates with pulse pressure and is highly familial.
It is concluded that telomere length, which is under genetic control, might play a role in mechanisms that regulate pulse pressure, including vascular aging.
Short telomeres on human chromosome 17p
It is demonstrated by quantitative fluorescence in situ hybridization (Q-FISH; ref. 7) that the number of T2AG3 repeats on specific chromosome arms is very similar in different tissues from the same donor and varies only to some extent between donors.
Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes.
DS patients showed a significantly higher rate of telomere loss with donor age compared with age-matched controls, suggesting that accelerated telomeres loss is a biomarker of premature immunosenescence of DS patients and that it may play a role in this process.
Telomere shortening in atherosclerosis
Telomere Length as an Indicator of Biological Aging: The Gender Effect and Relation With Pulse Pressure and Pulse Wave Velocity
The longer telomere length in women suggests that for a given chronological age, biological aging of men is more advanced than that of women, such that men with shorter telomeres length are more likely to exhibit high pulse pressure and pulse wave velocity, which are indices of large artery stiffness.
The implication of telomerase activity and telomere stability for replicative aging and cellular immortality (Review).
This review aims to summarize important results in the rapidly moving field of telomeres and telomerase.