Telomere Length as an Indicator of Biological Aging: The Gender Effect and Relation With Pulse Pressure and Pulse Wave Velocity

@article{Benetos2001TelomereLA,
  title={Telomere Length as an Indicator of Biological Aging: The Gender Effect and Relation With Pulse Pressure and Pulse Wave Velocity},
  author={Athanase Benetos and Koji Okuda and Malika Lajemi and Masayuki Kimura and Fr{\'e}d{\'e}rique Thomas and Joan H. Skurnick and Carlos Labat and Kathryn E Bean and Abraham Aviv},
  journal={Hypertension: Journal of the American Heart Association},
  year={2001},
  volume={37},
  pages={381-385}
}
  • A. BenetosK. Okuda A. Aviv
  • Published 1 February 2001
  • Biology
  • Hypertension: Journal of the American Heart Association
Chronological age is the primary determinant of stiffness of central arteries. Increased stiffness is an independent indicator of cardiovascular risk. The aim of this study was to determine whether telomere length, a possible index of biological aging, provides a better account than chronological age for variation in arterial stiffness, evaluated by measuring pulse pressure and aortic pulse wave velocity. The study population included 193 French subjects (120 men, 73 women), with a mean age of… 
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Telomere Length and Arterial Stiffness Reflected by Brachial–Ankle Pulse Wave Velocity: A Population-Based Cross-Sectional Study

Evidence of the factors influencing CVD risks at a very early stage when individuals can still take necessary precautions before CVD gives rise to a symptomatic health outcome is provided.

Leukocyte telomere length is inversely associated with arterial wave reflection in 566 normotensive and never-treated hypertensive subjects

To conclude, augmentation index was predominantly related with chronological aging, but also with mean LTL, suggesting that this variable of central wave reflection is a modest marker of vascular biological aging.

Association of shorter mean telomere length with large artery stiffness in patients with coronary heart disease

The data show an association of leukocyte telomere length shortening with increased arterial stiffness and cardiovascular burden, suggesting that telomeres length is a biomarker of large artery elasticity and CAD.

Reduced telomere length is not associated with early signs of vascular aging in young men born after intrauterine growth restriction: a paradox?

Unexpectedly, in this cohort, the SGA group had longer telomeres than the normal controls, which could indicate a faster telomere attrition rate and probable early onset of cardiovascular risk in SGA participants.

Short telomere length is associated with renal impairment in Japanese subjects with cardiovascular risk

In this Japanese sample of persons with increased cardiovascular risk, telomere length showed a relationship of longer telomeres length to better renal function, but did not overall show convincing association with cardiovascular measures of arterial stiffness and target organ damage.

Association of Insulin Resistance, Arterial Stiffness and Telomere Length in Adults Free of Cardiovascular Diseases

The data suggest that IR is associated with cell senescence and arterial aging and could, therefore, become the main target in preventing accelerated arterial Aging, besides blood pressure control.

Impact of biological aging on arterial aging in American Indians: findings from the Strong Heart Family Study

In summary, shorter LTL was significantly associated with an increased arterial stiffness, independent of known risk factors, which may shed light on the potential role of biological aging in arterial aging in American Indians.

On Cross-Sectional Associations of Leukocyte Telomere Length with Cardiac Systolic, Diastolic and Vascular Function: The Asklepios Study

In a generally healthy, young to middle-aged population, PBL TL is not related to LV mass or systolic function, but might be associated with an altered LV filling pattern, especially in women.

Short Telomere Length is Associated with Aging, Central Obesity, Poor Sleep and Hypertension in Lebanese Individuals

This is the first study in Lebanon to show an association between age, central obesity, poor sleep and hypertension and RTL, and it is hoped that telomere length measurement be potentially used as a biomarker for biological age and age-related diseases and progression in the Lebanese.
...

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