Telomere Dysfunction Increases Mutation Rate and Genomic Instability

@article{Hackett2001TelomereDI,
  title={Telomere Dysfunction Increases Mutation Rate and Genomic Instability},
  author={Jennifer A. Hackett and David M Feldser and Carol W Greider},
  journal={Cell},
  year={2001},
  volume={106},
  pages={275-286}
}
The increased tumor incidence in telomerase null mice suggests that telomere dysfunction induces genetic instability. To test this directly, we examined mutation rate in the absence of telomerase in S. cerevisiae. The mutation rate in the CAN1 gene increased 10- to 100-fold in est1Delta strains as telomeres became dysfunctional. This increased mutation rate resulted from an increased frequency of terminal deletions. Chromosome fusions were recovered from est1Delta strains, suggesting that the… CONTINUE READING
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