Telomere Dynamics in Human Cells Reprogrammed to Pluripotency

  title={Telomere Dynamics in Human Cells Reprogrammed to Pluripotency},
  author={Steven Thomas Suhr and Eun Ah Chang and Ram{\'o}n Mar{\'i}a Rodr{\'i}guez and Kai Wang and Pablo Juan Ross and Zeki Beyhan and Shashanka Murthy and Jose Bernardo Cibelli},
  booktitle={PloS one},
BACKGROUND Human induced pluripotent stem cells (IPSCs) have enormous potential in the development of cellular models of human disease and represent a potential source of autologous cells and tissues for therapeutic use. A question remains as to the biological age of IPSCs, in particular when isolated from older subjects. Studies of cloned animals indicate that somatic cells reprogrammed to pluripotency variably display telomere elongation, a common indicator of cell "rejuvenation… CONTINUE READING


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