Telomerase reverse transcriptase promoter mutations in bladder cancer: high frequency across stages, detection in urine, and lack of association with outcome.

@article{Allory2014TelomeraseRT,
  title={Telomerase reverse transcriptase promoter mutations in bladder cancer: high frequency across stages, detection in urine, and lack of association with outcome.},
  author={Yves Allory and Willemien Beukers and Ana Sagrera and Marta Fl{\'a}ndez and Miriam Marqu{\'e}s and Mirari M{\'a}rquez and Kirstin A van der Keur and Lars Dyrskjot and Irene Lurkin and M. J. M. Vermeij and Alfredo Carrato and Josep Lloreta and Jose Antonio Lorente and Enrique Carrillo-de Santa Pau and Roy G Masius and Manolis Kogevinas and Ewout Willem Steyerberg and Angela A. G. van Tilborg and Cheno S Abas and Torben Falck Orntoft and Tahlita C. M. Zuiverloon and N{\'u}ria Malats and Ellen C. Zwarthoff and Francisco X Real},
  journal={European urology},
  year={2014},
  volume={65 2},
  pages={360-6}
}
BACKGROUND Hotspot mutations in the promoter of the gene coding for telomerase reverse transcriptase (TERT) have been described and proposed to activate gene expression. OBJECTIVES To investigate TERT mutation frequency, spectrum, association with expression and clinical outcome, and potential for detection of recurrences in urine in patients with urothelial bladder cancer (UBC). DESIGN, SETTING, AND PARTICIPANTS A set of 111 UBCs of different stages was used to assess TERT promoter… CONTINUE READING
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