Telomerase reverse transcriptase promoter mutations in bladder cancer: high frequency across stages, detection in urine, and lack of association with outcome.

@article{Allory2014TelomeraseRT,
  title={Telomerase reverse transcriptase promoter mutations in bladder cancer: high frequency across stages, detection in urine, and lack of association with outcome.},
  author={Y. Allory and W. Beukers and Ana Sagrera and M. Flandez and M. Marqu{\'e}s and M. M{\'a}rquez and Kirstin A van der Keur and L. Dyrskj{\o}t and I. Lurkin and M. Vermeij and A. Carrato and J. Lloreta and J. A. Lorente and E. Carrillo-de Santa Pau and R. Masius and M. Kogevinas and E. Steyerberg and A. V. van Tilborg and Cheno Abas and T. Orntoft and T. Zuiverloon and N. Malats and E. Zwarthoff and F. Real},
  journal={European urology},
  year={2014},
  volume={65 2},
  pages={
          360-6
        }
}
  • Y. Allory, W. Beukers, +21 authors F. Real
  • Published 2014
  • Medicine
  • European urology
  • BACKGROUND Hotspot mutations in the promoter of the gene coding for telomerase reverse transcriptase (TERT) have been described and proposed to activate gene expression. OBJECTIVES To investigate TERT mutation frequency, spectrum, association with expression and clinical outcome, and potential for detection of recurrences in urine in patients with urothelial bladder cancer (UBC). DESIGN, SETTING, AND PARTICIPANTS A set of 111 UBCs of different stages was used to assess TERT promoter… CONTINUE READING
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