Telomerase reverse transcriptase gene amplification in hepatocellular carcinoma.

  title={Telomerase reverse transcriptase gene amplification in hepatocellular carcinoma.},
  author={Yoshitaka Takuma and Kazuhiro Nouso and Yoshiyuki Kobayashi and Shinichiro Nakamura and Hironori Tanaka and Eiji Matsumoto and Tatsuya Fujikawa and Mayumi Suzuki and Tadashi Hanafusa and Yasushi Shiratori},
  journal={Journal of gastroenterology and hepatology},
  volume={19 11},
BACKGROUND AND AIM Telomerase activation is essential for the immortality of cancer cells. The expression of telomerase reverse transcriptase (hTERT), the catalytic component of the telomerase complex, regulates telomerase activity in human cancers. Amplification of the hTERT gene, located at chromosome 5p, is thought to be a potential genetic event contributing to telomerase activation in sporadic tumors. METHODS The amplification of the hTERT gene was examined in 46 surgically resected… CONTINUE READING

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