Telomerase reverse transcriptase (TERT) expression and proliferation in canine brain tumours.

  title={Telomerase reverse transcriptase (TERT) expression and proliferation in canine brain tumours.},
  author={Sam N. Long and David John Argyle and Colin Nixon and Ian Nicholson and Catherine Botteron and Natasha J Olby and Simon R. Platt and Kenneth Smith and Gerard Roel Rutteman and Guy C. M. Grinwis and Lubna Nasir},
  journal={Neuropathology and applied neurobiology},
  volume={32 6},
Telomerase is a ribonucleoprotein enzyme complex that synthesizes telomere DNA. It is detected in 85-90% of malignant tumours in humans, but not in most somatic cells. Because telomerase plays a critical role in cell immortality, it represents an important target for anticancer therapies. We have previously shown that the dog is a potentially useful model for evaluating telomerase-based therapeutics. In this present study we analysed 93 canine brain tumours for telomerase reverse transcriptase… CONTINUE READING
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