Telomerase reconstitution immortalizes human fetal hepatocytes without disrupting their differentiation potential.

@article{Wege2003TelomeraseRI,
  title={Telomerase reconstitution immortalizes human fetal hepatocytes without disrupting their differentiation potential.},
  author={Henning Wege and Hai Thanh Le and Michael S Chui and Li Liu and Jian Wu and Ranjit Giri and Harmeet Malhi and Baljit Singh Sappal and Vinay Kumaran and Sanjeev M. Gupta and Mark A. Zern},
  journal={Gastroenterology},
  year={2003},
  volume={124 2},
  pages={432-44}
}
BACKGROUND & AIMS The availability of in vitro expandable human hepatocytes would greatly advance liver-directed cell therapies. Therefore, we examined whether human fetal hepatocytes are amenable to telomerase-mediated immortalization without inducing a transformed phenotype and disrupting their differentiation potential. Telomerase is a ribonucleoprotein that plays a pivotal role in maintaining telomere length and chromosome stability. Human somatic cells, including hepatocytes, exhibit no… CONTINUE READING