Telomerase modulates Wnt signalling by association with target gene chromatin

@article{Park2009TelomeraseMW,
  title={Telomerase modulates Wnt signalling by association with target gene chromatin},
  author={Jae-Il Park and Andrew S Venteicher and Ji yeon Hong and Jinkuk Choi and Sohee Jun and Marina Shkreli and Woody Chang and Zhaojing Meng and Peggie Cheung and Hong Ji and Margaret M. McLaughlin and Timothy D. Veenstra and Roel Nusse and P. D. Mccrea and Steven E. Artandi},
  journal={Nature},
  year={2009},
  volume={460},
  pages={66-72}
}
Stem cells are controlled, in part, by genetic pathways frequently dysregulated during human tumorigenesis. Either stimulation of Wnt/β-catenin signalling or overexpression of telomerase is sufficient to activate quiescent epidermal stem cells in vivo, although the mechanisms by which telomerase exerts these effects are not understood. Here we show that telomerase directly modulates Wnt/β-catenin signalling by serving as a cofactor in a β-catenin transcriptional complex. The telomerase protein… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 302 CITATIONS

Telomerase governs immunomodulatory properties of mesenchymal stem cells by regulating FAS ligand expression

  • EMBO molecular medicine
  • 2014
VIEW 11 EXCERPTS
CITES RESULTS, BACKGROUND & METHODS
HIGHLY INFLUENCED

PAF and EZH2 induce Wnt/β-catenin signaling hyperactivation.

  • Molecular cell
  • 2013
VIEW 4 EXCERPTS
CITES METHODS & BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2009
2019

CITATION STATISTICS

  • 25 Highly Influenced Citations

  • Averaged 25 Citations per year over the last 3 years

References

Publications referenced by this paper.
SHOWING 1-10 OF 53 REFERENCES

Similar Papers

Loading similar papers…