Telomerase is regulated by protein kinase C-zeta in human nasopharyngeal cancer cells.

@article{Yu2001TelomeraseIR,
  title={Telomerase is regulated by protein kinase C-zeta in human nasopharyngeal cancer cells.},
  author={Chia-Jung Yu and Samuel C-L Lo and Timothy C Wang},
  journal={The Biochemical journal},
  year={2001},
  volume={355 Pt 2},
  pages={459-64}
}
Telomerase, a specialized ribonucleoprotein reverse transcriptase that directs the synthesis of telomeric DNA, is repressed in normal human somatic cells, but is activated in most cancers. Little is known concerning how telomerase activity is activated and maintained in cancer cells. We have shown previously that inhibition of protein kinase C (PKC) decreases the telomerase activity of human nasopharyngeal carcinoma (NPC) cells. Here, we provide evidence that the decrease of telomerase activity… CONTINUE READING

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