Telomerase-inhibitory effects of the triphosphate derivatives of some biologically active nucleosides.

@article{Yamaguchi2001TelomeraseinhibitoryEO,
  title={Telomerase-inhibitory effects of the triphosphate derivatives of some biologically active nucleosides.},
  author={Toshiharu Yamaguchi and Yuko Takayama and Masakazu Saito and Fuyuki Ishikawa and Mineo Saneyoshi},
  journal={Nucleic acids research. Supplement},
  year={2001},
  volume={1},
  pages={211-2}
}
Telomerase is a ribonucleoprotein reverse transcriptase that uses its internal RNA moiety as a template for synthesis of telomere repeats. To clarify the susceptibility of telomerase to HIV-1 reverse transcriptase inhibitors (RT), we investigated the inhibitory effects of 3'-azido-3'-deoxythymidine 5'-triphosphate (AZTTP), which is known to be a potent HIV-1 RT inhibitor, and acyclovir triphosphate (ACVTP). Lineweaver-Burk plot analyses showed that the inhibition mode of these compounds was… CONTINUE READING