Telomerase inhibition by non-nucleosidic compound BIBR1532 causes rapid cell death in pre-B acute lymphoblastic leukemia cells.

@article{Bashash2013TelomeraseIB,
  title={Telomerase inhibition by non-nucleosidic compound BIBR1532 causes rapid cell death in pre-B acute lymphoblastic leukemia cells.},
  author={Davood Bashash and Seyed H Ghaffari and Rooholah Mirzaee and Kamran Alimoghaddam and Ardeshir Ghavamzadeh},
  journal={Leukemia & lymphoma},
  year={2013},
  volume={54 3},
  pages={
          561-8
        }
}
Since unlimited proliferative potential has been identified as a major and, to date, therapeutically unexploited phenotypic hallmark of cancer, telomere maintenance mechanisms have been proposed as potential targets for new anticancer interventions. This study was aimed to investigate the effects of BIBR1532, the lead compound of non-nucleosidic inhibition of telomerase, on pre-B acute lymphoblastic leukemia (ALL) cells. BIBR1532 caused rapid cell death in Nalm-6 cells probably through… CONTINUE READING