Telomerase inhibition by an siRNA directed against hTERT leads to telomere attrition in HT29 cells.

@article{Nascimento2006TelomeraseIB,
  title={Telomerase inhibition by an siRNA directed against hTERT leads to telomere attrition in HT29 cells.},
  author={Patr{\'i}cia de Souza Nascimento and Gilda Alves and Wolfgang Fiedler},
  journal={Oncology reports},
  year={2006},
  volume={16 2},
  pages={423-8}
}
Human telomerase is a ribonucleoprotein complex composed of at least the reverse catalytic transcriptase hTERT and RNA component hTR. The enzyme stabilizes telomere length and thereby contributes to unlimited cell proliferation, i.e. immortality. Reactivation of telomerase activity during carcinogenesis is a common hallmark in most human tumor types. Consequently, telomerase is an attractive molecular target toward which to direct cancer therapeutic agents. RNA interference (RNAi) has been… CONTINUE READING

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