Telomerase-immortalized non-malignant human prostate epithelial cells retain the properties of multipotent stem cells.

@article{Li2008TelomeraseimmortalizedNH,
  title={Telomerase-immortalized non-malignant human prostate epithelial cells retain the properties of multipotent stem cells.},
  author={Hongzhen Li and Jianjun Zhou and Jun Miki and Bungo Furusato and Yongpeng Gu and Shiv Srivastava and David G. Mcleod and Jonathan C. Vogel and Johng S. Rhim},
  journal={Experimental cell research},
  year={2008},
  volume={314 1},
  pages={92-102}
}
Understanding prostate stem cells may provide insight into the origin of prostate cancer. Primary cells have been cultured from human prostate tissue but they usually survive only 15-20 population doublings before undergoing senescence. We report here that RC-170N/h/clone 7 cells, a clonal cell line from hTERT-immortalized primary non-malignant tissue-derived human prostate epithelial cell line (RC170N/h), retain multipotent stem cell properties. The RC-170N/h/clone 7 cells expressed a human… CONTINUE READING