Telomerase expression extends the proliferative life-span and maintains the osteogenic potential of human bone marrow stromal cells

Abstract

Human bone marrow stromal cells (hMSCs) were stably transduced by a retroviral vector containing the gene for the catalytic subunit of human telomerase (hTERT). Transduced cells (hMSC-TERTs) had telomerase activity, and the mean telomere length was increased as compared with that of control cells. The transduced cells have now undergone more than 260… (More)
DOI: 10.1038/nbt0602-592

5 Figures and Tables

Topics

  • Presentations referencing similar topics