Telomerase expression and telomere length in breast cancer and their associations with adjuvant treatment and disease outcome

@inproceedings{Lu2011TelomeraseEA,
  title={Telomerase expression and telomere length in breast cancer and their associations with adjuvant treatment and disease outcome},
  author={Lingeng Lu and Chong Zhang and Gongjian Zhu and Melinda L. Irwin and Harvey A. Risch and Guido Menato and Marco Mitidieri and Dionyssios Katsaros and Herbert Yu},
  booktitle={Breast Cancer Research},
  year={2011}
}
Telomere length plays important roles in maintaining genome stability and regulating cell replication and death. Telomerase has functions not only to extend telomere length but also to repair DNA damage. Studies have shown that telomerase may increase cancer cell resistance to DNA-damaging anticancer agents; tamoxifen may suppress telomerase expression in breast cancer cells. This study aimed to investigate the role of telomere length and telomerase activity in breast cancer prognosis. qPCR and… CONTINUE READING